Effects of cannabinoids and cocaine on traumatic brain injury: A look at translational medicine

Solapas principales

Maiguel J.1, Muñoz K.1, Quiroz R.1 , Ramos Y.1,2,, Moscote L.2




            Cranioencephalic trauma (TBI) is a major public health problem worldwide, consequently the list of causes of death from injuries in the population under 45 years, affecting mainly the male gender. Through the ages, cannabinoids such as marijuana have been used in various fields, despite its harmful effects on the CNS, currently it is effectively presented in patients with TBI, for neuroplasticity and neuroinflammation neurodegeneration, as well as helping in the revascularization of the cerebral microvasculature. The administration of cocaine induces the release of transcription regulated by cocaine and amphetamine (CART), which is an element that has protective actions against ischemic lesions, since it plays an important role in the respiratory chain. Cocaine also reduces post-traumatic weight loss and increases cerebral blood flow. In this article it is said that the existing evidence refers to the applications of substances such as cocaine and cannabinoid derivatives in patient management


Key Words: Traumatic brain injury, cannabinoids, medical marijuana, cocaine.

  1. Estudiante de Medicina, Centro de Investigaciones Biomédicas (CIB), línea Cartagena Neurotrauma Research Group. Universidad de Cartagena.
  2. Médico. Especialista en Neurocirugía. Faculta de Medicina – Universidad de Cartagena. Cartagena de Indias, Bolívar