Cerebral proliferative angiopathy: Series of 3 cases

Solapas principales

Romero M.1,2,3, Jaume A.1,2,3, Negrotto M.3, Lin Lou T.3, Moragues R.1, Martinez F.1, Spagnuolo E. 2.



            Cerebral vascular malformations have an incidence of 6%, and are classified in many ways depending on topography, morphology, and / or demographics. With respect to the latter division, these malformations can be classified into malformations non proliferative or proliferative type. Proliferative lesions are divided into: Moya-Moya (M-M), proliferative cerebral angiopathy (ACP), and hemangiomas.

Three patient was presented who was assisted at CEDIVA, where he diagnosis of vascular proliferative lesion the type ACP by cerebral angiography.

PCA is a rare malformation, with an adult frequency of 3.4%, and M-M has a higher incidence in Japan (3: 100,000). Both are more frequent in females, but APC has an average presentation at about 22 years, while M-M has two presentation peaks: one at 5 and one at 40 years old. Usually these types of proliferative lesions present clinically as cerebrovascular accidents (strokes) of ischemic cause. The standard gold study for the diagnosis of these malformations is cerebral angiography. The APCs are malformations of great size being able to occupy an entire lobe or hemisphere, with innumerable glasses that extend between neurons and normal white matter. In most cases the treatment is aimed at improving circulatory hypoperfusion in order to prevent new ischemic events.

APC is a rare disease, whose early and correct diagnosis is important, since it has implications for treatment and prognosis.


Key Words: vascular malformation; proliferative lesions; ischemic;  endovascular treatment; surgery; prognosis.

  1. Servicio de Neurocirugía, Hospital de Clínicas, Montevideo. Uruguay.
  2. Servicio de Neurocirugía, Hospital Maciel, Montevideo. Uruguay.
  3. Centro de diagnóstico e intervencionismo vascular (CEDIVA), Montevideo, Uruguay