Multicentric and multifocal gliomas. Report two cases and revision

Solapas principales

Romero M.1, Jaume A.1, Bentacourt V.1, Martinez F.1, Spagnuolo E.2



            Multicenter and multifocal gliomas are unusual lesions of the central nervous system and are within the entity of multiple gliomas. We present two illustrious clinical cases, one patient with a multicentric WHO grade III anaplastic Oligodendroglioma, with two lesions one left frontal and one right temporal. A second clinical case of a patient with a multifocal Glioblastoma multiforme, with two lesions right, one frontal and one temporal. Through the same are sought to make an update of the subject, pointing to the diagnosis and clinical form of presentation of a very rare pathology. A bibliographic review focused on multiple, multicentric and multifocal gliomas was carried out until 2017, in Pubmed ( to review and update the most controversial points of this pathology.  The etiopathogenesis, frequency and especially the differential diagnosis with other multiple lesions of the central nervous system, as well as its treatment and prognosis are discussed. Treatment remains controversial, from complete resection to stereotactic biopsy. The histopathological diagnosis is fundamental to differentiate them from other multiple brain lesions and for the therapeutic planning. Despite technological advances, the prognosis remains bleak and survival is still less than 6 months for people who appear earlier and 8 months for people who appear late

Key Words: Glioma multiple, Glioma multicentric, Glioma multifocal, Glioblastoma multiforme, multiple brain lesions , multicentric Oligodendroglioma, multicéntric Glioblastoma multiforme, supra e infratentorial lesions.


  1. Departamento de Neurocirugía, Hospital de Clínicas – Dr. Manuel Quintela, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
  2.  Servicio de Neurocirugía Hospital Maciel – Centro de Entrenamiento Neuroquirúrgico, FLANC, Montevideo, Uruguay